The Piccadilly Theatre is a West End theatre located at 16 Denman Street, behind Piccadilly Circus and adjacent to the Regent Palace Hotel, in the City of Westminster, England.
Built by Bertie Crewe and Edward A. Stone for Edward Laurillard, its simple facade conceals a grandiose Art Deco interior designed by Marc-Henri Levy and Gaston Laverdet, with a 1,232-seat auditorium decorated in shades of pink. Gold and green are the dominant colours in the bars and foyer, which include the original light fittings. Upon its opening on 27 April 1928, the theatre's souvenir brochure claimed, "If all the bricks used in the building were laid in a straight line, they would stretch from London to Paris." The opening production, Jerome Kern's musical Blue Eyes, starred Evelyn Laye, one of the most acclaimed actresses of the period.
The Piccadilly is one of twenty-four venues owned by the Ambassador Theatre Group. It is one of the 40 theatres featured in the 2012 DVD documentary series Great West End Theatres, presented by Donald Sinden.